Path of Exile. Hands down.
I just broke 1400 hours and still going strong. There’s so much to do and so much to learn, and it’s so good at rewarding grinding and keeping you chasing those incremental improvements. It’s 100% replaced RuneScape for me.
I have broken 1000 hours with Cookie Clicker, Guild Wars 2, RuneScape, and Eve Online. I don’t recommend the latter two anymore, but CC and GW2 still hold up.
Honorable mention to Factorio. I’m still in the hundreds but it’s climbing.
There’s a moose loose in the hoose.