I mean, in response to the last one, the Federation does allow (and sometimes advocates) for the correction of birth defects.
Julian: DNA resequencing for any reason other than repairing serious birth defects is illegal. Any genetically enhanced human being is barred from serving in Starfleet or practising medicine.
Deep Space Nine, “Doctor Bashir, I presume”
Doctor: Yes. It’s a girl. And aside from the deviated spine, she’s healthy.
Paris: Will she need surgery?
Doctor: Fortunately, we’ve advanced beyond that. Genetic modification is the treatment of choice.
Voyager, “Lineage”
So I imagine plenty of disabilities do end up being erased, it’s just that being disabled is also socially accepted to a much greater extent than today.
And Intel. Intel has been using TSMC fabs for a while.
They used to get a 40% discount, too, but that stopped recently when Pat Gelsinger said people should stop buying from TSMC because there’s a good chance they’ll be invaded.
TSMC’s CEO didn’t like that, and said “ok, no more 40% discount for you. Effective immediately.” (TL;DR’d, obviously).