Seriously, the city is so big and detailed that I feel like Cyberpunk 2077 only scratched the surface of it. Night City is the heart of Cyberpunk and moving to a whole new location would be a huge bummer to me.

Ideally it would take place maybe 10 years after 2077 and maybe another bomb went off or something and turned a big chunk of downtown into a wasteland and now Pacifica/Dogtown is the new hot area.

Supplement this by making part of the story take place on the moon and/or the Crystal Palace and allowing you to travel back and forth like in Witcher 3 and I think that will feel plenty fresh for a whole new game + a couple of expansions.